"South Asia is a region of extraordinary hope as demonstrated by its aggressive growth over the past decade," Guerrero was quoted as saying in a statement.
It is also a region in which the range of profound human challenges stand out starkly, from poverty to conflict to tremendous environmental management issues.
"Finding solutions in South Asia means finding solutions to some of the most intractable problems facing our world.
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Guerrero said her time in India had also demonstrated to her the region's phenomenal capacity to find those solutions with the sort of innovation and intellectual creativity that was already driving the sub-continent into the world's imagination.
World Bank chief Robert Zoellick said she brought to the task a strong track record in development.
During her