Opener Vandiar led the way at one of the most famous world cricket venues with his runs coming off 48 balls as he mixed aggression and patience in a knock that included three sixes and four fours.
It took two household cricket names to terminate his clever stand with Tendulkar catching a half-volley off the bowling of Sri Lankan Lasith Malinga 16.
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3 overs into the innings.
Neil McKenzie was the other Lion to roar before a near-full crowd in the 30,000-seat stadium, coming in at number five and finishing unbeaten on 56 off 30 balls with seven fours and a six to lift a sagging innings.
Having cruised to 83 without loss, Mumbai surrendered two wickets while adding just six to their total midway through the innings as opener Shikhar Dhawan exited after amassing 32 and Ambati Rayudu was run out for three.
Tendulkar finally fell after 14.3 overs having scored 69 as he drifted to the leg side only to be clean bowled as Shane Burger sent the stumps flying amid much relief among his team-mates.