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"We couldn't afford to treat them all without these generic drugs," said Joanna Keenan, spokesman for the Geneva-based charity.
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The warning came as India's Supreme Court was due Tuesday to hear more arguments in an appeal by Novartis seeking patent protection for its leukaemia drug Glivec in a case watched closely by the global pharmaceutical industry.
"If the patent law challenge is successful, it would have a devastating impact on access to affordable medicines across the developing world," said Leena Menghaney, India representative of Medecins Sans Frontieres (MSF).
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Novartis is "trying to shut down the pharmacy of the developing world," she said.
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The Supreme Court case is the final act in a legal battle between Novartis and patient groups which has stretched over six years in India, where local firms produce generic versions of branded drugs for a fraction of their price.
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Pharmaceutical companies argue that protecting patents are crucial to stimulating the research and develop