The more than four days of talks resulted in the first global agreement struck by the Geneva-based body since its 1995 founding.
The accord includes commitments to facilitate trade by simplifying customs procedures, which some economists have said could give a trillion jolt to the world economy.
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"For the first time in our history, the WTO has truly delivered," an exhausted-looking WTO director-general Roberto Azevedo told a closing ceremony. The agreement falls far short of the WTO's lofty but elusive vision of tearing down trade barriers around the world through its frustrating, 12-year-old Doha Round of talks.
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But Azevedo said it could have important symbolic value for the trade body's hopes of kick-starting Doha.
"The decisions we have taken here are an important stepping-stone toward the completion o