The dog was in quarantine after being brought into Britain from Sri Lanka.
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"This animal died whilst in quarantine, which has effectively contained any public health risk," said Doctor Dilys Morgan, an HPA rabies expert.
"We understand that three individuals connected to the quarantine centre and rescue centre were bitten by the animal and all have received or will be receiving prompt protective treatment with appropriate vaccination.
"Even if someone has been bitten by an animal with rabies, prompt post-exposure treatment following the bite is highly effective in preventing rabies." .