The tourists, electing to bat on a wicket that provided early assistance to the seamers, slumped to their lowest total against Sri Lanka after being reduced to 19-4 by the seventh over of the match.
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Sri Lanka ended the opening day at 164-3 in reply, leaving them well-placed to build on the 50-run win in the first Test at Galle last week that gave them the lead in the three-match series.
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Skipper Kumar Sangakkara led the way with an unbeaten 81 after adding 54 for the second wicket with Tharanga Paranavitana and 51 for the third with Mahela Jayawardene.
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Sri Lanka's left-arm fast bowler Thilan Thushara chipped in with two wickets and spinner Ajantha Mendis dismissed the last three batsmen as Pakistan were shot out in 36 overs 45 minutes after lunch.
Former Pakistan captain Shoaib Malik was the lone batsman to defy the Sri Lankan bowlers at the P. Sara Oval, returning unbeaten on 39.
Pakistan caved in just as they had done in the second innings of the Galle Test where, needing 9