Dvkovic, the 20-year-old revelation of the year, showed remarkable composure in defeating Spanish veteran Carlos Moya 6-4, 7-6 (9/7), 6-1.
Ferrer, better-known as a never-say-die claycourter, reached his first Grand semi by brushing aside the challenge of Argentina's Juan Ignacio Chela 6-2, 6-3, 7-5.
The two have met three times previously with Ferrer holding a 2-1 advantage, although Djokovic won their only hardcourt encounter to date at Indian Wells in March.
Red-hot favourite Federer was already through to the semi-finals with his straight sets defeat of Andy Roddick late Wednesday.
The Swiss star will take on Russia's Nikolay Davydenko, against whom he has a perfect 9-0 record including a straight-sets win in last year's semi-finals at Flushing Meadows.
Rarely, all four quarter-finals resulted in straight-set victories.
Both semi-finals will be played on Saturday.
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Djokovic, who rose to No. 3 in the world after he beat Roddick, Rafael Nadal and Federer one after the othe